Ppp3r1tm1Grc
Targeted Allele Detail
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Symbol: |
Ppp3r1tm1Grc |
Name: |
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); targeted mutation 1, Gerald R Crabtree |
MGI ID: |
MGI:3043986 |
Synonyms: |
CnB* |
Gene: |
Ppp3r1 Location: Chr11:17109298-17150380 bp, + strand Genetic Position: Chr11, 9.71 cM, cytoband A3.1
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Alliance: |
Ppp3r1tm1Grc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:70266
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted |
Mutation: |
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Other
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Mutation details: Sequence encoding an FRB* peptide tag was inserted into exon 5, immediately following the last codon of the coding sequence. This allele produces a protein with a C-terminal FRB* peptide tag that prevents interaction with PPP3CA, thereby eliminating calcium-dependent activation of PPP3CA catalytic activity. An assay indicated the abrogation of caclcineurin phosphatase activity.
(J:70266)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ppp3r1 Mutation: |
31 strains or lines available
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Original: |
J:70266 Graef IA, et al., Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75 |
All: |
1 reference(s) |
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