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Ppp3r1tm1Grc
Targeted Allele Detail
Summary
Symbol: Ppp3r1tm1Grc
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); targeted mutation 1, Gerald R Crabtree
MGI ID: MGI:3043986
Synonyms: CnB*
Gene: Ppp3r1  Location: Chr11:17109298-17150380 bp, + strand  Genetic Position: Chr11, 9.71 cM, cytoband A3.1
Alliance: Ppp3r1tm1Grc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70266
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Other
 
Mutation detailsSequence encoding an FRB* peptide tag was inserted into exon 5, immediately following the last codon of the coding sequence. This allele produces a protein with a C-terminal FRB* peptide tag that prevents interaction with PPP3CA, thereby eliminating calcium-dependent activation of PPP3CA catalytic activity. An assay indicated the abrogation of caclcineurin phosphatase activity. (J:70266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp3r1 Mutation:  31 strains or lines available
References
Original:  J:70266 Graef IA, et al., Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory