Il1rl1^tm1Brl
Targeted Allele Detail

Summary

• Symbol: Il1rl1^tm1Brl
• Name: interleukin 1 receptor-like 1; targeted mutation 1, RCC, Ltd
• MGI ID: MGI:3043989
• Synonyms: TgH(GS-T1)Brl
• Gene: Il1rl1 Location: Chr1:40468730-40504575 bp, + strand Genetic Position: Chr1, 19.19 cM
• Alliance: Il1rl1^tm1Brl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63507
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 4.8 kb of the endogenous gene, including part of exon 2 and all of exons 3 to 6, were deleted and replaced by the lacZ gene followed by a neomycin resistance gene. Expression of the endogenous gene was abolished. Expression of beta-galactosidase was not reported. (J:63507)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il1rl1 Mutation: 59 strains or lines available

References

• Original: J:63507 Senn KA, et al., T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis. Eur J Immunol. 2000 Jul;30(7):1929-38
• All: 4 reference(s)