Ppp3r1^tm2Grc
Targeted Allele Detail

Summary

• Symbol: Ppp3r1^tm2Grc
• Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); targeted mutation 2, Gerald R Crabtree
• MGI ID: MGI:3044022
• Synonyms: Cnb1^f, Cnb1^flox, CnB1-LoxP
• Gene: Ppp3r1 Location: Chr11:17109298-17150380 bp, + strand Genetic Position: Chr11, 9.71 cM, cytoband A3.1
• Alliance: Ppp3r1^tm2Grc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89771
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 through 5 were flanked by single loxP sites. A single frt site remained in intron 3 following FLP-mediated excition of an frt-flanked neo cassette. (J:89771)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp3r1 Mutation: 31 strains or lines available

References

• Original: J:89771 Neilson JR, et al., Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004 Mar;20(3):255-66
• All: 44 reference(s)