H2-T23^tm1Cant
Targeted Allele Detail

Summary

• Symbol: H2-T23^tm1Cant
• Name: histocompatibility 2, T region locus 23; targeted mutation 1, Harvey Cantor
• MGI ID: MGI:3044027
• Synonyms: Qa-1^-, Qa-1b^-, Qa-1 KO
• Gene: H2-T23 Location: Chr17:36340869-36343593 bp, - strand Genetic Position: Chr17, 18.86 cM
• Alliance: H2-T23^tm1Cant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89808
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 - 3 were replaced with a neo cassette via homologous recombination. This insertion introduced a frameshift. The absence of protein expression in activated thymocytes and splenic T cells was confirmed by flow cytometry. (J:89808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-T23 Mutation: 35 strains or lines available

References

• Original: J:89808 Hu D, et al., Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol. 2004 Jun;5(5):516-23
• All: 24 reference(s)