Ppp3r1^tm2.1Grc
Targeted Allele Detail

Summary

• Symbol: Ppp3r1^tm2.1Grc
• Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); targeted mutation 2.1, Gerald R Crabtree
• MGI ID: MGI:3044031
• Synonyms: Cnb1^delta
• Gene: Ppp3r1 Location: Chr11:17109298-17150380 bp, + strand Genetic Position: Chr11, 9.71 cM, cytoband A3.1
• Alliance: Ppp3r1^tm2.1Grc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89771
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of the single loxP sites in Ppp3r1^tm2Grc resulted in the deletion of exons 3 through 5. (J:89771)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp3r1 Mutation: 30 strains or lines available

References

• Original: J:89771 Neilson JR, et al., Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004 Mar;20(3):255-66
• All: 9 reference(s)