Tg(SERPINA1-IGHG1/Il1rl1)423Zbz
Transgene Detail

Summary

• Symbol: Tg(SERPINA1-IGHG1/Il1rl1)423Zbz
• Name: transgene insertion 423, University Hospital, Zurich
• MGI ID: MGI:3044038
• Synonyms: T1-Fc, TgN423AAT-T1FcZbz, Tg(SERPIN1A-IGHG1/Il1rl1)423Zbz
• Transgene: Tg(SERPINA1-IGHG1/Il1rl1)423Zbz Location: unknown
• Alliance: Tg(SERPINA1-IGHG1/Il1rl1)423Zbz page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SERPINA1-IGHG1/Il1rl1)423Zbz expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGHG1 (3500)

  Ighg	(MGI:2144967)
  Ighg1	(MGI:96446)
  Ighg2a	(MGI:96443)
  Ighg2b	(MGI:96445)
  Ighg2c	(MGI:2686979)
  Ighg3	(MGI:2144790)

  mouse

  Il1rl1 (MGI:98427)
• Mutation details: The transgene comprises a cDNA encoding the extracellular domain of IL1RL1 fused to the Fc portion of human IgG gamma 1 under control of the liver-specific promoter of the human SERPIN1A gene. The soluble fusion protein is secreted into the serum. (J:63507)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:63507 Senn KA, et al., T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis. Eur J Immunol. 2000 Jul;30(7):1929-38
• All: 2 reference(s)