Drd3^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Drd3^tm1Stl
• Name: dopamine receptor D3; targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:3044114
• Synonyms: D3^-, D3R^-, D3R KO
• Gene: Drd3 Location: Chr16:43574389-43643295 bp, + strand Genetic Position: Chr16, 28.44 cM
• Alliance: Drd3^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43791
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exon 1. Southern blot analysis confirmed recombination. Autoradiographic analysis confirmed the absence of Drd3 binding sites in brains of homozygous mice. (J:43791)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd3 Mutation: 59 strains or lines available

References

• Original: J:43791 Xu M, et al., Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 1997 Oct;19(4):837-48
• All: 30 reference(s)