Tfec^tm1Est
Targeted Allele Detail

Summary

• Symbol: Tfec^tm1Est
• Name: transcription factor EC; targeted mutation 1, Eirikur Steingrimsson
• MGI ID: MGI:3044120
• Synonyms: Tfec^Fcr
• Gene: Tfec Location: Chr6:16833372-16898440 bp, - strand Genetic Position: Chr6, 7.61 cM, cytoband E4-G
• Alliance: Tfec^tm1Est page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89821
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5 kb genomic fragment encompassing 2 exons and encoding a portion of the bHLH-Zip domain was replaced with a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of renal RNA obtained from homozygous mutant mice. (J:89821)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfec Mutation: 25 strains or lines available

References

• Original: J:89821 Steingrimsson E, et al., Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4477-82
• All: 2 reference(s)