Scel^tm1Hba
Targeted Allele Detail

Summary

• Symbol: Scel^tm1Hba
• Name: sciellin; targeted mutation 1, Howard P Baden
• MGI ID: MGI:3044133
• Synonyms: Scel^-
• Gene: Scel Location: Chr14:103750778-103850233 bp, + strand Genetic Position: Chr14, 52.51 cM, cytoband E
• Alliance: Scel^tm1Hba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100664
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Chimeric mice with this allele were generated by Incyte Genomic Inc, Palo Alto CA. Exons 2 and 3 were replaced with a neomycin resistance gene. This resulted in the deletion of the initiation codon found normally in exon 2. Northern and Western blots failed to detect transcript or protein in mutants, respectively. (J:100664)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scel Mutation: 46 strains or lines available

References

• Original: J:100664 Baden HP, et al., Targeted deletion of the sciellin gene resulted in normal development and maturation. Genesis. 2005 Aug;42(4):219-28
• All: 1 reference(s)