Hsf1^tm1Anak
Targeted Allele Detail

Summary

• Symbol: Hsf1^tm1Anak
• Name: heat shock factor 1; targeted mutation 1, Akira Nakai
• MGI ID: MGI:3044161
• Gene: Hsf1 Location: Chr15:76361562-76385355 bp, + strand Genetic Position: Chr15, 35.95 cM
• Alliance: Hsf1^tm1Anak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90551
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a neo cassette. Exons 2 and 3 encode the DNA-binding domain. Southern blot confirmed recombination. (J:89846)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsf1 Mutation: 25 strains or lines available

References

• Original: J:90551 Inouye S, et al., Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures. Mol Cell Biol. 2003 Aug;23(16):5882-95
• All: 31 reference(s)