Hip1^tm2.1Tsr
Targeted Allele Detail

Summary

• Symbol: Hip1^tm2.1Tsr
• Name: huntingtin interacting protein 1; targeted mutation 2.1, Theodora S Ross
• MGI ID: MGI:3044188
• Synonyms: Hip1^delta3-5
• Gene: Hip1 Location: Chr5:135435385-135573974 bp, - strand Genetic Position: Chr5, 75.18 cM, cytoband F-G2
• Alliance: Hip1^tm2.1Tsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90400
• Parent Cell Line: RW1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination excised floxed exons 3-5 and the neo cassette in Hip1^tm2Tsr. Western blot analysis of mutant brains confirmed absence of protein. Phenotypic analysis suggests that this allele may be a hypomorph. (J:90400)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hip1 Mutation: 67 strains or lines available

References

• Original: J:90400 Oravecz-Wilson KI, et al., Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet. 2004 Apr 15;13(8):851-67
• All: 2 reference(s)