rsl
Spontaneous Allele Detail

Summary

• Symbol: rsl
• Name: regulator of sex limited protein-Slp
• MGI ID: MGI:3044189
• Synonyms: Rsl1^-, rsl^FM, rsl^PL
• Gene: rsl Location: Chr13:56629249-72385140 bp Genetic Position: Chr13, Syntenic
• Alliance: rsl page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: The Slp gene is normally expressed in male mice, but it is expressed in females in the strains FM, LG, NZB, and PL due to a mutation in the rsl gene(s). The rsl (regulator of sex limited protein-Slp) phenotype is attributable to mutations in both the Rsl1 and Rsl2 genes. Both a small deletion of Rsl2 and a G-to-T transversion mutation that affects transcript splicing of Rsl1 appear to affect sexually dimorphic expression of male-specific genes, although only the mutation in Rsl1 appears to cause the loss of sex-limited expression of Slp. (J:86324)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any rsl Mutation: 1 strain or line available

References

• Original: J:84442 Brown LJ, et al., Female expression of the H-2-linked sex-limited protein (Slp) due to non-H-2 genes. Immunogenetics. 1980;10(1):19-29
• All: 6 reference(s)