Abcb1a^mds
Spontaneous Allele Detail

Summary

• Symbol: Abcb1a^mds
• Name: ATP-binding cassette, sub-family B member 1A; multiple drug sensitive
• MGI ID: MGI:3044239
• Synonyms: mdr1a^-, mdr-3
• Gene: Abcb1a Location: Chr5:8710077-8798575 bp, + strand Genetic Position: Chr5, 3.43 cM
• Alliance: Abcb1a^mds page

Abcb1a^mds/Abcb1a^mds mice exhibit selective neurologic ivermectin toxicity in the hippocampal CA3 field that is not seen in wild-type mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: CF-1

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: The analysis of the genomic locus revealed an insertion of a solo long terminal repeat (LTR) of the ecotropic murine leukemia virus in the reverse orientation in the intron of the mdr-3 gene, causing abnormal splicing and thereby disrupting the mdr-3 gene function. This allele is also present in strains SAMP1, SAMP6, SAMP7, SAMP9, SAMR1, SAMR4 and SAMR5. The identical mutation is found in Crl:CF1 mice. (J:64725, J:208754)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Abcb1a Mutation: 93 strains or lines available

References

• Original: J:40292 Lankas GR, et al., P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity. Toxicol Appl Pharmacol. 1997 Apr;143(2):357-65
• All: 11 reference(s)