Mnt^tm1.1Awb
Targeted Allele Detail

Summary

• Symbol: Mnt^tm1.1Awb
• Name: max binding protein; targeted mutation 1.1, Anthony Wynshaw-Boris
• MGI ID: MGI:3044352
• Synonyms: Mnt^-
• Gene: Mnt Location: Chr11:74721746-74736551 bp, + strand Genetic Position: Chr11, 45.76 cM, cytoband B-C
• Alliance: Mnt^tm1.1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90397
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination was used to excise the floxed hygro and exons 4-6 in Mnt^tm1Awb. Western blot confirmed absence of protein in mutant embryos. (J:90397)

Disease models

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mnt Mutation: 26 strains or lines available

References

• Original: J:90397 Toyo-oka K, et al., Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004 May 15;13(10):1057-67
• All: 2 reference(s)