Twsg1^tm1Emdr
Targeted Allele Detail

Summary

• Symbol: Twsg1^tm1Emdr
• Name: twisted gastrulation BMP signaling modulator 1; targeted mutation 1, E M De Robertis
• MGI ID: MGI:3044357
• Synonyms: Tsg^-, Twsg1^lacZ
• Gene: Twsg1 Location: Chr17:66230060-66258198 bp, - strand Genetic Position: Chr17, 35.26 cM
• Alliance: Twsg1^tm1Emdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90398
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In-frame insertion of a lacZ reporter into exon 1 at the start codon resulted in the deletion of exon 1, which encodes the first 40 amino acids of the protein, including the entire signal peptide. RT-PCR indicated no transcript present in mutant embryonic cells. (J:90398)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Twsg1 Mutation: 20 strains or lines available

References

• Original: J:90398 Zakin L, et al., Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development. 2004 Jan;131(2):413-24
• All: 5 reference(s)