Nr1i3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Nr1i3^tm1Dgen
• Name: nuclear receptor subfamily 1, group I, member 3; targeted mutation 1, Deltagen
• MGI ID: MGI:3044371
• Synonyms: CAR -, Nr1i3^tm1Sakl
• Gene: Nr1i3 Location: Chr1:171041503-171046414 bp, + strand Genetic Position: Chr1, 79.21 cM
• Alliance: Nr1i3^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90553
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Nucleotides 38 to 159 of the open reading frame including the region encoding for the first zinc finger of the DNA binding domain were deleted by homologous recombination. This recombination event introduced a frameshift. (J:90553)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1i3 Mutation: 36 strains or lines available

References

• Original: J:90553 Maglich JM, et al., Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol. 2002 Sep;62(3):638-46
• All: 5 reference(s)