Capop^NOD
QTL Variant Detail

Summary

• QTL variant: Capop^NOD
• Name: cyclophosphamide induced apoptosis; NOD
• MGI ID: MGI:3044388
• QTL: Capop Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 33.72 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to gamma irradiation induced T cell apoptosis compared to C57BL/6. (J:68151)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68151

100 (C57BL/6 x NOD)F2 animals were treated with gamma-irradiation and assessed for T-cell apoptosis. Linkage analysis was conducted using markers near previously identified Idd (insulin dependent diabetes susceptibility) loci to find association between diabetes and resistance to T-cell apoptosis. T-cells harvested from NOD animals are resistant to experimentally induced apoptosis whereas T-cells from C57BL/6 animals are susceptible to experimentally induced apoptosis. Significant linkage to apoptosis resistance to was detected in a 3 cM region on mouse Chromosome 1 from 30.5 cM - 32.8 cM overlapping Idd5 (P = 0.000086 at D1Mit21). Authors name this locus Capop (cyclophosphamide induced apoptosis) and confirmed the locus in congenic strain NOD.B6-C1.1 carrying the NOD-derived Idd5 on a C65BL/6 background. NOD.B6-C1.1 exhibits resistance to induced T-cell apoptosis similar to parental strain NOD. Genes mapping near Capop include Ctla4, Cd28, Cflar, Casp8, and Icos. Cd152 deficient mice show similar resistance to gamma-irradiation induced T-cell apoptosis as NOD mice and is a likely candidate gene for Capop and/or Idd5.

References

• Original: J:68151 Bergman ML, et al., CTLA-4-/- Mice Display T Cell-apoptosis Resistance Resembling that Ascribed to Autoimmune-prone Non-obese Diabetic (NOD) Mice. J Autoimmun. 2001 Mar;16(2):105-13
• All: 1 reference(s)