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Cora1BALB/c
QTL Variant Detail
Summary
QTL variant: Cora1BALB/c
Name: correlation in cytokine production 1; BALB/c
MGI ID: MGI:3044391
QTL: Cora1  Location: Chr5:132156883-132157015 bp  Genetic Position: Chr5, cM position of peak correlated region/allele: 71.21 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  BALB/c
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsAnimals homozygous for this allele display increased cytokine production after stimulation with ConA compared to heterozygous animals. (J:52119)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52119

The strains BALB/cHeA and STS/A differ in the production of Il4 and Il10 after stimulation with concanavalin A (ConA). The genetic basis of this difference was analyzed using the recombinant congenic (RC) strains of the BALB/c - c - STS/Dem (CcS/Dem) series. The authors analyzed correlation between expression of Il4 and Il10 in 80 (CcS-20 x BALB/c)F2 hybrids after stimulation with ConA at a novel QTL, Cora1, marked by D5Mit63 on mouse Chromosome 5. Higher correlation was observed in homozygotes in either the BALB/c or STS/A allele than in heterozygotes (P = 0.0448).

References
Original:  J:52119 Kosarova M, et al., The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Immunogenetics. 1999 Feb;49(2):134-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory