Cora1^STS/A
QTL Variant Detail

Summary

• QTL variant: Cora1^STS/A
• Name: correlation in cytokine production 1; STS/A
• MGI ID: MGI:3044392
• QTL: Cora1 Location: Chr5:132156883-132157015 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 71.21 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Animals homozygous for this allele display increased cytokine production after stimulation with ConA compared to heterozygous animals. (J:52119)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52119

The strains BALB/cHeA and STS/A differ in the production of Il4 and Il10 after stimulation with concanavalin A (ConA). The genetic basis of this difference was analyzed using the recombinant congenic (RC) strains of the BALB/c - c - STS/Dem (CcS/Dem) series. The authors analyzed correlation between expression of Il4 and Il10 in 80 (CcS-20 x BALB/c)F2 hybrids after stimulation with ConA at a novel QTL, Cora1, marked by D5Mit63 on mouse Chromosome 5. Higher correlation was observed in homozygotes in either the BALB/c or STS/A allele than in heterozygotes (P = 0.0448).

References

• Original: J:52119 Kosarova M, et al., The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Immunogenetics. 1999 Feb;49(2):134-41
• All: 1 reference(s)