Cypr1^STS/A
QTL Variant Detail

Summary

• QTL variant: Cypr1^STS/A
• Name: cytokine production 1; STS/A
• MGI ID: MGI:3044396
• QTL: Cypr1 Location: Chr16:49312795-49312933 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 30.92 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased Il4 production after stimulation with ConA compared to BALB/c. (J:52119)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52119

The strains BALB/cHeA and STS/A differ in the production of Il4 and Il10 after stimulation with concanavalin A (ConA). The genetic basis of this difference was analyzed using the recombinant congenic (RC) strains of the BALB/c - c - STS/Dem (CcS/Dem) series. The authors analyzed Il4 expression in 164 (CcS-20 x BALB/c)F2 hybrids after stimulation with 2.5 an 5 micrograms/ml ConA. Statistical evaluation revealed linkage of Il4 expression induced by 5 micrograms/ml for 48 hours and 2.5 micrograms/ml for 72 hours to the marker D16Mit15 on mouse Chromosome 16 (corrected P = 0.046 and 0.0062 respectively). The STS allele indicates higher il4 concentration. These data indicated the presence of a QTL, Cypr1 in this region controlling the Il4 level induced by polyclonal stimulation of ConA.

References

• Original: J:52119 Kosarova M, et al., The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Immunogenetics. 1999 Feb;49(2):134-41
• All: 1 reference(s)