Cypr2^BALB/c
QTL Variant Detail

Summary

• QTL variant: Cypr2^BALB/c
• Name: cytokine production 2; BALB/c
• MGI ID: MGI:3044398
• QTL: Cypr2 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased Il10 production after stimulation with ConA compared to STS/A. (J:52119)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52119

The strains BALB/cHeA and STS/A differ in the production of Il4 and Il10 after stimulation with concanavalin A (ConA). The genetic basis of this difference was analyzed using the recombinant congenic (RC) strains of the BALB/c - c - STS/Dem (CcS/Dem) series. The authors analyzed Il10 expression in 80 (CcS-20 x BALB/c)F2 hybrids after stimulation with 2.5 micrograms/ml ConA. Statistical evaluation revealed linkage of Il10 expression induced by 2.5 micrograms/ml ConA to the markers D1Mit14 and D1Mit227 (P = 0.0111 and 0.0155 respectively). These data indicate the presence of a QTL, Cypr2, controlling the Il10 level induced by polyclonal stimulation by ConA in the distal end of mouse Chromosome 1. Higher production was seen with the BALB/c allele of this locus.

References

• Original: J:52119 Kosarova M, et al., The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Immunogenetics. 1999 Feb;49(2):134-41
• All: 1 reference(s)