Cypr3^BALB/c
QTL Variant Detail

Summary

• QTL variant: Cypr3^BALB/c
• Name: cytokine production 3; BALB/c
• MGI ID: MGI:3044401
• QTL: Cypr3 Location: Chr5:98019649-98019803 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 47.77 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased Il10 production after stimulation with ConA compared to STS/A. (J:52119)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52119

The strains BALB/cHeA and STS/A differ in the production of Il4 and Il10 after stimulation with concanavalin A (ConA). The genetic basis of this difference was analyzed using the recombinant congenic (RC) strains of the BALB/c - c - STS/Dem (CcS/Dem) series. The authors analyzed Il10 expression in 80 (CcS-20 x BALB/c)F2 hybrids after stimulation with 5.0 micrograms/ml ConA. Statistical evaluation revealed linkage of Il10 expression induced by 5.0 micrograms/ml ConA to D5Mit20 (P = 0.039). These data indicate the presence of a QTL, Cypr3, controlling the Il10 level induced by polyclonal stimulation by ConA in the central part of mouse Chromosome 5. Higher production was seen with the BALB/c allele of this locus.

References

• Original: J:52119 Kosarova M, et al., The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Immunogenetics. 1999 Feb;49(2):134-41
• All: 1 reference(s)