Ar^tm1Reb
Targeted Allele Detail

Summary

• Symbol: Ar^tm1Reb
• Name: androgen receptor; targeted mutation 1, Robert E Braun
• MGI ID: MGI:3044436
• Synonyms: Ar^{flox(ex1-neo)}
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1Reb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90393
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo and a single loxP sequence were inserted 3' of exon 1. An additional inverted loxP site was inserted 5' of exon 1. Southern blot of mutant ES cells confirm recombination. (J:90393)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

Notes

ES cell line = FWB2.

References

• Original: J:90393 Holdcraft RW, et al., Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development. 2004 Jan;131(2):459-67
• All: 5 reference(s)