Gck^Gena348
Chemically induced Allele Detail

Summary

• Symbol: Gck^Gena348
• Name: glucokinase; Gena348, Harwell
• MGI ID: MGI:3044558
• Synonyms: Gck^I366F, Gena348
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^Gena348 page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to T transversion is found at position 1096 in exon 9. This results in a missense amino acid change from isoleucine to phenylalanine at position 366. Western blot analysis did not find any significant change in protein expression although glucose phosphorylating activity was significantly impaired. This mutation was generated as part of the Harwell/SB ENU mutagenesis project. (J:90389, J:137483)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 63 strains or lines available

References

• Original: J:90389 Toye AA, et al., A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes. 2004 Jun;53(6):1577-83
• All: 6 reference(s)