Tg(ACTB-NOTCH1)1Shn
Transgene Detail

Summary

• Symbol: Tg(ACTB-NOTCH1)1Shn
• Name: transgene insertion 1, Jie Shen
• MGI ID: MGI:3044583
• Synonyms: CALSL-NICD
• Transgene: Tg(ACTB-NOTCH1)1Shn Location: unknown
• Alliance: Tg(ACTB-NOTCH1)1Shn page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-NOTCH1)1Shn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NOTCH1 (4851)

  Notch1

  (MGI:97363)

• Mutation details: This transgene consists of the chicken beta-actin promoter followed by a loxP flanked stop, the human NOTCH1 intracellular domain (amino acids 1762-2304), and an SV40 late polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the NOTCH1 gene. Only single site insertions were used to generate mice. This line carries 10 - 20 copies of the transgene and protein is detectable by western blot analysis after cre mediated recombination. (J:90392)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
• All: 7 reference(s)