Tg(Actb-NOTCH1)2Shn
Transgene Detail

Summary

• Symbol: Tg(Actb-NOTCH1)2Shn
• Name: transgene insertion 2, Jie Shen
• MGI ID: MGI:3044584
• Synonyms: CALSL-NICD(L)
• Transgene: Tg(Actb-NOTCH1)2Shn Location: unknown
• Alliance: Tg(Actb-NOTCH1)2Shn page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Actb-NOTCH1)2Shn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NOTCH1 (4851)

  Notch1

  (MGI:97363)

• Mutation details: This transgene consists of the chicken Actb followed by a loxP flanked stop, the human NOTCH1 intracellular domain (amino acids 1762-2304) and an SV40 late polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the NOTCH1 gene. Only single site insertions were used to generate mice. This line carries 1 - 2 copies of the transgene and no protein is detectable by western blot analysis after cre mediated recombination. (J:90392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
• All: 2 reference(s)