Notch1^tm2Rko
Targeted Allele Detail

Summary

• Symbol: Notch1^tm2Rko
• Name: notch 1; targeted mutation 2, Raphael Kopan
• MGI ID: MGI:3044585
• Synonyms: fN1, N1^f, NICD1^fl, Notch1^f, Notch1^flox, Notch1^tm1Shn
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm2Rko page

Corneal plaques and increased angiogenesis in the ear of Notch1^tm2Rko/Notch1^tm3(cre)Rko mice

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90392
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP were inserted flanking the first coding exon of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:90392)

Expression

In Mice Carrying this Mutation:	52118 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Notch1^tm2Rko

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
• All: 121 reference(s)