Tcf7l1^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Tcf7l1^tm1Efu
• Name: transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:3044615
• Synonyms: Tcf3^LoxP
• Gene: Tcf7l1 Location: Chr6:72603354-72766028 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Tcf7l1^tm1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90402
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 64 bp segment of exon 2 was flanked with loxP sites via homologous recombination. A loxP flanked neo cassette was removed via cre mediated recombination prior to generation of chimeric mice. (J:90402)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l1 Mutation: 84 strains or lines available

References

• Original: J:90402 Merrill BJ, et al., Tcf3: a transcriptional regulator of axis induction in the early embryo. Development. 2004 Jan;131(2):263-74
• All: 4 reference(s)