Sigmar1^tm1Lmon
Targeted Allele Detail

Summary

• Symbol: Sigmar1^tm1Lmon
• Name: sigma non-opioid intracellular receptor 1; targeted mutation 1, Lluis Montoliu
• MGI ID: MGI:3044771
• Synonyms: mSR1-, Sig1R^-, sigma1R KO
• Gene: Sigmar1 Location: Chr4:41738493-41741359 bp, - strand Genetic Position: Chr4, 22.05 cM, cytoband A5-B2
• Alliance: Sigmar1^tm1Lmon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89669
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame lacZ gene and neo cassette were inserted after the first 4 codons deleting 1907 bases via homologous recombination. Northern and western blot analysis confirmed the absence of mRNA and protein expression in homozygous mice. (J:89669)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sigmar1 Mutation: 21 strains or lines available

References

• Original: J:89669 Langa F, et al., Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice. Eur J Neurosci. 2003 Oct;18(8):2188-96
• All: 23 reference(s)