Rgs1^tm1Jhk
Targeted Allele Detail

Summary

• Symbol: Rgs1^tm1Jhk
• Name: regulator of G-protein signaling 1; targeted mutation 1, John H Kehrl
• MGI ID: MGI:3044786
• Synonyms: Rgs1-
• Gene: Rgs1 Location: Chr1:144120407-144124862 bp, - strand Genetic Position: Chr1, 62.56 cM
• Alliance: Rgs1^tm1Jhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90780
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo gene was inserted into exon 1 via homologous recombination disrupting the first coding exon and exon splice donor site. Immunoblotting of B-cell lysates after immunization confirmed the absence of protein expression in homozygous mice. Expression of clustered and related Rgs genes was unaffected. (J:90780)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs1 Mutation: 24 strains or lines available

References

• Original: J:90780 Moratz C, et al., Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice. Mol Cell Biol. 2004 Jul;24(13):5767-75
• All: 8 reference(s)