Cnot7^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Cnot7^tm1Tno
• Name: CCR4-NOT transcription complex, subunit 7; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:3044887
• Synonyms: Cnot7-
• Gene: Cnot7 Location: Chr8:40945581-40968888 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Cnot7^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90439
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ with a nuclear localization signal and a pMC1 neo polyA fragment were inserted in-frame into the exon containing the first methionine via homologous recombination. Northern and western blot analysis confirmed the absence of RNA and protein expression in homozygous mutants. LacZ expression was detected in the seminiferous tubules. (J:90439)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnot7 Mutation: 28 strains or lines available

References

• Original: J:90439 Nakamura T, et al., Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 2004 May;36(5):528-33
• All: 6 reference(s)