Ptpn2^tm1Mtr
Targeted Allele Detail

Summary

• Symbol: Ptpn2^tm1Mtr
• Name: protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1, Michel L Tremblay
• MGI ID: MGI:3044910
• Synonyms: tc-ptp^-, tcptp^-
• Gene: Ptpn2 Location: Chr18:67798581-67857665 bp, - strand Genetic Position: Chr18, 40.06 cM
• Alliance: Ptpn2^tm1Mtr page

Decreased number of stromal cells in Ptpn2^tm1Mtr/Ptpn2^tm1Mtr bone marrow

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42595
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced 1.5 exons which encoded amino acids 64-121. This rendered the gene product enzymatically nonfunctional. Lack of gene transcription was demonstrated by Northern blot analysis and absence of protein was confirmed by Western blot. (J:42595)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn2 Mutation: 44 strains or lines available

References

• Original: J:42595 You-Ten KE, et al., Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997 Aug 29;186(5):683-93
• All: 17 reference(s)