Tbx18^tm1Akis
Targeted Allele Detail

Summary

• Symbol: Tbx18^tm1Akis
• Name: T-box18; targeted mutation 1, Andreas Kispert
• MGI ID: MGI:3044914
• Synonyms: Tbx18-
• Gene: Tbx18 Location: Chr9:87584853-87613313 bp, - strand Genetic Position: Chr9, 47.06 cM, cytoband E3.2
• Alliance: Tbx18^tm1Akis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90513
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene followed by a floxed neo cassette were inserted into the 5'-untranslated region of exon 1 via homologous recombination deleting part of exon 1. Down-regulation and absence of RNA expression was confirmed by in situ hybridization. LacZ expression does not recapitulate endogenous expression. (J:90513)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx18 Mutation: 36 strains or lines available

References

• Original: J:90513 Bussen M, et al., The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev. 2004 May 15;18(10):1209-21
• All: 5 reference(s)