Fgf15^tm1Sms
Targeted Allele Detail

Summary

• Symbol: Fgf15^tm1Sms
• Name: fibroblast growth factor 15; targeted mutation 1, Suzanne L Mansour
• MGI ID: MGI:3044957
• Gene: Fgf15 Location: Chr7:144450269-144454690 bp, + strand Genetic Position: Chr7, 88.92 cM
• Alliance: Fgf15^tm1Sms page

Fgf15^tm1Sms/Fgf15^tm1Sms mice display cardiovascular defects

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90407
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 3, which is the last coding exon, was replaced with a neomycin selection cassette inserted by homologous recombination. RT-PCR analysis of homozygous mutant embryos indicated an absence of normal transcript, but identified a mutant transcript containing exons 1 and 2. The mutant transcript lacks exon 3 sequence and therefore does not encode the putative HSPG and FGFR binding sites. (J:90407)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf15 Mutation: 15 strains or lines available

References

• Original: J:90407 Wright TJ, et al., Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev Biol. 2004 May 1;269(1):264-75
• All: 26 reference(s)