Pgia36^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Pgia36^DBA/1J
• Name: proteoglycan induced arthritis 36; DBA/1J
• MGI ID: MGI:3044982
• QTL: Pgia36 Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:89536

Linkage analysis at an average resolution of 10 cM was performed on 3 separate mouse crosses to map QTLs associated with proteoglycan-induced arthritis (PGIA) and collagen-induced arthritis (CIA).

559 (BALB/c x DBA/2)F2 MHC-matched animals and 402 (BALB/c x DBA/1J)F2 MHC-unmatched animals were analyzed for linkage to PGIA. 537 (BALB/c x DBA/1J)F2 animals were analyzed for linkage to CIA.

With respect to PGIA, parental strain BALB/c is highly susceptible whereas parental strains DBA/2 and DBA/1J are fully resistant. As expected, (BALB/c x DBA/2)F1 hybrids are resistant to PGIA, but interestingly (BALB/c x DBA/1J)F1 hybrids are susceptible to PGIA. This is unusual because the BALB/c allele typically exhibits recessive susceptibility to disease, but thisisnot the case with the cross to DBA/1J.

With respect to CIA, parental strain DBA/1J is highly susceptible whereas parental strains BALB/c and DBA/2 are fully resistant. All F1s exhibited susceptibility to CIA.

Pgia18 mapped to proximal mouse Chromosome 5 in association with PGIA susceptibility and severity (LOD=5) in MHC-unmatched (BALB/c x DBA/1J)F2 populations.

Pgia36 mapped to distal mouse Chromosome 5 in association with PGIA susceptibility and severity (LOD=9) in the MHC-unmatched (BALB/c x DBA/1J)F2 population. Pgia16 overlaps with Cia13 and Cia14 (mCia10 and mCia11, used respectivey in Figure 3) .

References

• Original: J:89536 Glant TT, et al., Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Am J Med Sci. 2004 Apr;327(4):188-95
• All: 1 reference(s)