Pgia40^BALB/cCrl
QTL Variant Detail

Summary

• QTL variant: Pgia40^BALB/cCrl
• Name: proteoglycan induced arthritis 40; BALB/cCrl
• MGI ID: MGI:3044994
• QTL: Pgia40 Location: Chr13:44918469-44918560 bp Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: BALB/cCrl

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:84150

Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.

Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.

The authors cite the following marker as having been previously mapped; however, differing parental strains were used in the previous map studies. We have renamed the QTL as follows:

The authors refer to Pgia15 on Chromosome 13. This QTL was originally mapped using (C57BL/6x C3H/HeJCr)F2 intercrossd mice in J:65424. We have renamed this QTL, mapped here using (BALB/cCrl x DBA/2Crl)F2, as Pgia40. This QTL maps to mouse chromosome 13 at D13Mit179 with a LOD=4.1 in female mice for disease suceptibility. The Pgia40 interval spanned 0-47cM on chr 13.

References

• Original: J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
• All: 1 reference(s)