Prnp^a
Spontaneous Allele Detail

Summary

• Symbol: Prnp^a
• Name: prion protein; a
• MGI ID: MGI:3045029
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^a page

Mutation origin

• Strain of Origin: NZW

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: The protein product for this allele has a Leucine (L) at amino acid residue 108 and a Threonine (T) at amino acid residue 189. DNA from the NZW mouse was originally sequenced. Other mouse strains with the same allele are: RIIS/J, C57BL/6J, CAST/Ei, MOLF/Ei, and MA/MyJ. (J:8918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 142 strains or lines available

References

• Original: J:8918 Westaway D, et al., Distinct prion proteins in short and long scrapie incubation period mice. Cell. 1987 Nov 20;51(4):651-62
• All: 5 reference(s)