Prnp^b
Spontaneous Allele Detail

Summary

• Symbol: Prnp^b
• Name: prion protein; b
• MGI ID: MGI:3045031
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^b page

Mutation origin

• Strain of Origin: I/LnJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: In this allele, amino acid residue 108 is Phenylalanine (F) and amino acid residue 189 is Valine (V). This allele was initially sequenced using DNA from the I/LnJ strain. The same allele has been identified in P/J, IM, and BDP/J. (J:8918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 142 strains or lines available

References

• Original: J:8918 Westaway D, et al., Distinct prion proteins in short and long scrapie incubation period mice. Cell. 1987 Nov 20;51(4):651-62
• All: 4 reference(s)