Nfe2l3^tm1Vbl
Targeted Allele Detail

Summary

• Symbol: Nfe2l3^tm1Vbl
• Name: nuclear factor, erythroid derived 2, like 3; targeted mutation 1, Volker Blank
• MGI ID: MGI:3045075
• Synonyms: Nrf3^-
• Gene: Nfe2l3 Location: Chr6:51409650-51435748 bp, + strand Genetic Position: Chr6, 24.84 cM
• Alliance: Nfe2l3^tm1Vbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89893
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons were replaced with a floxed neomycin-cytosine deamidase cassette. Transcripts lacked CNC homology, DNA binding, and leucine zipper domains. (J:89893)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l3 Mutation: 28 strains or lines available

References

• Original: J:89893 Derjuga A, et al., Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004 Apr;24(8):3286-94
• All: 4 reference(s)