Gfra1^tm1Bjh
Targeted Allele Detail

Summary

• Symbol: Gfra1^tm1Bjh
• Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1, B J Hoffer
• MGI ID: MGI:3045109
• Synonyms: GFRalpha1 -
• Gene: Gfra1 Location: Chr19:58224036-58444341 bp, - strand Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
• Alliance: Gfra1^tm1Bjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60458
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The first exons were replaced with a PGK-neomycin resistance cassette in reverse orientation. (J:60458)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra1 Mutation: 33 strains or lines available

References

• Original: J:60458 Tomac AC, et al., Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles. Neuroscience. 2000;95(4):1011-23
• All: 5 reference(s)