Recql4^tm1Glu
Targeted Allele Detail

Summary

• Symbol: Recql4^tm1Glu
• Name: RecQ protein-like 4; targeted mutation 1, Guangbin Luo
• MGI ID: MGI:3045113
• Synonyms: Recql4^-
• Gene: Recql4 Location: Chr15:76587753-76594748 bp, - strand Genetic Position: Chr15, 36.28 cM, cytoband D3
• Alliance: Recql4^tm1Glu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97101
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targted mutation replaces a 1075bp genomic fragment encompassing part of exon 9 through exon 13 of the Recql4 gene with a PGKhprt-mini gene cassette. (J:97101)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Recql4 Mutation: 46 strains or lines available

References

• Original: J:97101 Mann MB, et al., Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet. 2005 Mar 15;14(6):813-25
• All: 3 reference(s)