Or8a1^tm2Mom
Targeted Allele Detail

Summary

• Symbol: Or8a1^tm2Mom
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 2, Peter Mombaerts
• MGI ID: MGI:3045137
• Synonyms: Hyb B, M71-M72 hybrid B
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^tm2Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90716
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Eighteen bp changes resulting in 6 amino acid substitutions (A146V, V151M, A157T, G161S, V194I, D205N) and an IRES-taulacZ gene were introduced via homologous recombination. The resulting protein is a hybrid between Olfr151 and Olfr160 which have a total of 25 bp and 11 amino acid differences. The lacZ gene was fused after the stop codon and co-expressed with the mutant protein. (J:90716)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:90716 Feinstein P, et al., A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell. 2004 Jun 11;117(6):817-31
• All: 1 reference(s)