Jak2^tm1Kuw
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1Kuw
• Name: Janus kinase 2; targeted mutation 1, Kay-Uwe Wagner
• MGI ID: MGI:3045140
• Synonyms: Jak2^fl
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1Kuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90883
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The first coding exon (exon 2) was flanked by loxP sites. (J:90883)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Jak2^tm1Kuw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:90883 Wagner KU, et al., Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol. 2004 Jun;24(12):5510-20
• All: 45 reference(s)