Or8a1^tm5Mom
Targeted Allele Detail

Summary

• Symbol: Or8a1^tm5Mom
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 5, Peter Mombaerts
• MGI ID: MGI:3045141
• Synonyms: Hyb E
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^tm5Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90716
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Or8a1^tm5Mom expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Or8a1b (MGI:1931271)

• Mutation details: Three bp changes resulting in 2 amino acid substitutions (A146V, V151M) and an IRES-tauGFP gene were introduced via homologous recombination. The resulting protein is a hybrid between Olfr151 and Olfr160 which have a total of 25 bp and 11 amino acid differences. The GFP gene was fused after the stop codon and co-expressed with the mutant protein. (J:90716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:90716 Feinstein P, et al., A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell. 2004 Jun 11;117(6):817-31
• All: 1 reference(s)