Jak2^tm1.1Kuw
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1.1Kuw
• Name: Janus kinase 2; targeted mutation 1.1, Kay-Uwe Wagner
• MGI ID: MGI:3045147
• Synonyms: Jak2^-
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1.1Kuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90883
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Jak2^tm1Kuw in which the loxP-flanked exon 2 was deleted in the germline by Cre-mediated recombination. (J:90883)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:90883 Wagner KU, et al., Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol. 2004 Jun;24(12):5510-20
• All: 4 reference(s)