Jak2^tm1Kpf
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1Kpf
• Name: Janus kinase 2; targeted mutation 1, Klaus Pfeffer
• MGI ID: MGI:3045167
• Synonyms: Jak2^-
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47298
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the start codon and downstream sequence from exon 1. Protein was undetected by Western blot analysis of homozygous mutant embryonic fibroblasts. (J:47298)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:47298 Neubauer H, et al., Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998 May 1;93(3):397-409
• All: 6 reference(s)