Smad1^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Smad1^tm1Sor
• Name: SMAD family member 1; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:3045218
• Synonyms: Smad1^C
• Gene: Smad1 Location: Chr8:80065024-80126057 bp, - strand Genetic Position: Chr8, 37.56 cM
• Alliance: Smad1^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90769
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo was introduced upstream of exon 7, and within exon 7 the C-terminal SSVS motif was changed to AAVA. Cre-mediated recombination excised the neo, leaving the mutated exon 7. Western blot of embryonic protein extracts indicated that mutant embryos showed similar levels of protein as that in wild-type. (J:90769)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad1 Mutation: 32 strains or lines available

References

• Original: J:90769 Aubin J, et al., In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 2004 Jun 15;18(12):1482-94
• All: 1 reference(s)