Abcc6^tm1Jfk
Targeted Allele Detail

Summary

• Symbol: Abcc6^tm1Jfk
• Name: ATP-binding cassette, sub-family C member 6; targeted mutation 1 John F Klement
• MGI ID: MGI:3045236
• Synonyms: Abcc6^-
• Gene: Abcc6 Location: Chr7:45625804-45679915 bp, - strand Genetic Position: Chr7, 29.64 cM, cytoband B3
• Alliance: Abcc6^tm1Jfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101372
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 15-18 of the locus. Transcript proved to be absent in Northern blot analysis. (J:101372)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcc6 Mutation: 76 strains or lines available

References

• Original: J:101372 Klement JF, et al., Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol. 2005 Sep;25(18):8299-310
• All: 27 reference(s)