Fas^tm1Dlo
Targeted Allele Detail

Summary

• Symbol: Fas^tm1Dlo
• Name: Fas cell surface death receptor; targeted mutation 1, Dennis Y Loh
• MGI ID: MGI:3045400
• Synonyms: Fas^-
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^tm1Dlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31847
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene except for exon 1, which encodes half of the signal peptide, was replaced with a PGK-neo-poly(A) cassette. Absence of protein in mutants was confirmed by flow cytometry. (J:31847)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

References

• Original: J:31847 Senju S, et al., Functional significance of the Fas molecule in naive lymphocytes. Int Immunol. 1996 Mar;8(3):423-31
• All: 7 reference(s)