Pcyt1b^tm1Mkar
Targeted Allele Detail

Summary

• Symbol: Pcyt1b^tm1Mkar
• Name: phosphate cytidylyltransferase 1, choline, beta isoform; targeted mutation 1, Muhammad A Karim
• MGI ID: MGI:3045401
• Synonyms: CCTB2^-, CCTbeta2^-
• Gene: Pcyt1b Location: ChrX:92698469-92793557 bp, + strand Genetic Position: ChrX, 41.28 cM
• Alliance: Pcyt1b^tm1Mkar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90150
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo was inserted into exon 2, and a portion of the 3' coding sequence of exon 2 was deleted in the beta2 isoform. Northern blot indicated absence of transcript in brain, liver, lung, testes and ovaries of mutant mice. (J:90150)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcyt1b Mutation: 87 strains or lines available

References

• Original: J:90150 Jackowski S, et al., Disruption of CCT{beta}2 Expression Leads to Gonadal Dysfunction. Mol Cell Biol. 2004 Jun;24(11):4720-4733
• All: 3 reference(s)